Biochemist (f/m/x) - Düsseldorf, Deutschland - Universitätsklinikum Köln (AöR)

Beschreibung

Working at the University Hospital Cologne and the Medical Faculty means helping to shape the future - the future of medicine, of patients and, of course, your own future. You benefit from 60 clinics and institutes as well as numerous other departments and facilities and more than 12,000 jobs. The Faculty of Medicine of the University of Cologne and the University Hospital Cologne assume important social tasks in research, teaching and patient care. A close network with many university and non-university partners guarantees an internationally successful science and the excellent education of our students.

We are looking as soon as possible for a

Postdoctoral fellow (f/m/x) in the areas of cancer genetics, cancer cell biology and cancer immunology
at the Department of Translational Genomics

full-time; initially limited until June 30, 2027 (third-party funded project)

The research mission of the Department of Translational Genomics is to understand the impact of somatic genetic alterations in cancer cells on the highly complex regulatory network of signaling pathways. Therefore, we link basic research and the application of new findings with translational research to close the loop, linking disciplines and delivering therapies to patients more rapidly. The research project will leverage from research programs as part of the collaborative research center SFB1399 and the eMed systems medicine . The project will focus on the study of lung cancer. Our Department is highly interdisciplinary, covering expertise in cancer genomics as well as computational genomics, molecular biology, cancer immunology, mouse models, biochemistry and signaling, as well as structural biology, medicinal chemistry, structure-guided drug design and molecular pathology. We provide a vibrant environment ideal for personal growth and career advancements to pursue an international career in cancer research. The candidate will work closely with Prof. Dr. Roman Thomas and Prof. Dr. Julie George.

We build our Department on a portfolio of established technological platforms, covering approaches in genomics, immunomics, cellular models, genetically engineered mouse models (GEMMs) and imaging, as well as computational efforts to understand the molecular evolution of cancer. Particular emphasis is placed on carefully interrogating the discoveries made in large scale high-throughput assays in subsequent fine-grained mechanistic experiments. Our scientific efforts are intimately linked to the clinic through a translational platform, which facilitates the longitudinal molecular monitoring of patients, thus providing mechanisms of evolution and adaptation to therapy.

This is an exciting opportunity to be part of pioneering cancer research. Our aim is to study the molecular processes that drive initiation and progression of cancer. We employ state-of-the art genomics, single cell sequencing and profiling, functional genomics and proteomics to capture somatic changes in cancer cells, and the cellular networks that modulate processes of cancer malignancy. We seek to validate findings in vitro and in vivo in various models. Our work combines computational biology approaches with functional studies and cell biology approaches with the goal of discovering new targets for cancer (immuno-) therapy. We have in the last years provided comprehensive genome profiling of lung cancer patients, established a wide array of patient-derived tumor models and studied tumor evolutionary processes.

REFs

1. George, -, Thomas, Nature 2024.
2. Malchers,-,George, Thomas, JCI, 2023.
3. Drapkin, George, - Thomas, Cancer Discovery 2018.
4. George,-, Thomas, Nature Communications, 2018.
5. George, -, Thomas, Nature 2015.
6. Seidel, -, Thomas, Science Translational Medicine, 2014.

We are looking for a highly motivated and talented scientist driven by the desire to make a relevant contribution to the treatment of cancer patients through exciting scientific discoveries in the lab. The ability to work independently is a must. Successful candidates will have a strong background in basic molecular and cell biology, immunology, biochemistry, computational biology or similar areas.

Please submit your application including a detailed CV, list of publications, two references and a brief statement of research interests.

We offer a great work environment, intensive mentoring and several interactions with global leaders, both from academia and industry. In addition, the highly collaborative research environment in Cologne provides us with access to state-of-the-art core facilities, including genomics, proteomics and imaging.

Your salary will be based on TV-L