Entry-level Role As a Phd/postdoc Specializing in - Eppendorf, Deutschland - UKE - Universitätsklinikum Hamburg-Eppendorf

UKE - Universitätsklinikum Hamburg-Eppendorf

Geprüftes Unternehmen

Eppendorf, Deutschland

vor 1 Woche

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

Better together. For life.

We are the University Medical Center Hamburg-Eppendorf (UKE) - and we stand for excellent competence in research, teaching and comprehensive healthcare in our clinics.

Every day, our approximately 14,900 employees strive anew to make the world a little healthier with their contribution.

It is our aspiration to be one of the leading university hospitals - and at the same time the best employer in our industry.

At UKE, for example, we firmly believe that successful and fulfilling work should be in harmony with employees' personal needs and individual lifestyles.

And as diverse as these are, so is our range of individual solutions.

Welcome to the UKE.

Entry-level role as a PhD/Postdoc specializing in Tumor Immunology within a translational research project:

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Job-ID:

J
Working hours:

Temporary
Working hours:

Fulltime/Parttime
Organization:

UKE_Zentrum für Onkologie
Company section:

Research & Science
Department:
II. Med.

Klinik (Häma/Onko)
Main tasks:
***Cancer undergoes an intricate parasitic evolution, continuously evading detection by the immune system while orchestrating alterations within its surrounding microenvironment, known as the TME (Tumor Microenvironment). The TME possesses the ability to facilitate tumor progression and foster resistance to therapeutic interventions. In addition to intrinsic tumor factors, host-related elements, such as the microbiota, microbiota-derived metabolites, dietary metabolites, and hormones (collectively referred to as the macroenvironment), also play a crucial role in molding the local TME, potentially exacerbating cancer progression.

This research project will concentrate on gastrointestinal cancers, with a particular focus on pancreatic and colorectal cancers.

Employing cutting-edge multi-omic techniques like single-cell sequencing, shotgun metagenomic sequencing, and metabolomic screening, in conjunction with advanced murine cancer models and_ in vitro _systems, our aim is to unravel the intricate interplay between the TME and its macroenvironment in shaping cancer progression and therapy resistance.

For this undertaking, we have access to a continually expanding biobank containing pertinent human samples and well-established colorectal or pancreatic cancer mouse models.

Furthermore, our laboratory is equipped with fully operational multi-omic workflows and standardized analysis pipelines.

The ultimate ambition of this project is to elucidate specific molecular mechanisms underlying therapy resistance and to identify novel strategies to alleviate it.

Project supervision from a clinician scientist
Integration into a small project related team with close supervision and mentoring
Overall integration in a highly collaborative working environment of two working groups
Weekly discussion and feedback rounds with supervisors
Fully funded research project
Possibility to work with/establish state of the art techniques
Integration into structured institutional programs
This position is temporary for 2 years in case of a postdoc qualification or 3 years for PhD students

Your Profile:

***- Profound knowledge in basic biological methods and cell culture, especially cloning

Profound knowledge in either clinical immunology, microbiota, cancer biology or cancer metabolism
Prior knowledge in bioinformatic analysis of multiomic data and/or work with laboratory mice is preferred
High degree of
intrinsic motivation

Immunity status:

***
Our Offer:***- International and multidisciplinary environment at a leading European Institution, the University Medical Center Hamburg-Eppendorf (Germany)

Access to several sophisticated mouse models (germfree mice, cancer models, immune cell reporter mice), multiomics (singlecell sequencing; metabolomic screening; shotgun metagenomics) and human material for translational studies
Interdisciplinary project covering the tumor micro

- and macroenvironment

Weekly scientific exchange: lab meetings and journal clubs
National and international collaboration network
Access to the soft skills programme of the institution: e.g., presenting skills, scientific writing

Contact:

***
Contact to the department:
Dr

Joseph Tintelnot:

Recruiting contact:

Recruiting Team:

About us:

***
We live diversity and value variety
We offer a work environment providing equal opportunities regardless of age, gender, sexual identity, disability, origin or religion. This is confirmed by our accession to the Charter of Diversity.

We explicitly aim to increase the proportion of women in management positions, especially among scientific personnel in research and teaching.

Women with equal qualifications will be given priority. The same applies in the case of under-representation of one gender in the advertised area. Persons with severe disability with equa