Senior Research Assistant - Hamburg, Deutschland - Evotec

Evotec
Evotec
Geprüftes Unternehmen
Hamburg, Deutschland

vor 4 Wochen

Lena Wagner

Geschrieben von:

Lena Wagner

beBee Recruiter
Beschreibung
The
_Target ID and Validation_ team within the
_In Vitro Biology | Early Discovery _department in Hamburg is looking for an enthusiastic, creative and passionate:
Senior Research Assistant (all genders)

Target Identification / CRISPR

Full-time and permanent


Your key responsibilities:

  • Develop and optimize cellbased and biochemical assays in 96 and/or 384well plate format for a wide range of readout technologies to evaluate their effect upon CRISPRmediated gene manipulation at mediumtohigh throughput scale
  • Adapt and miniaturize cellbased assays to highthroughput genetic perturbation screening workflows on robotic liquid handling platforms
  • Establish and optimize cellular assays to assess the effects of genetic perturbations (e.g. CRISPR and RNAi) for target identification/validation using Sanger sequencing, NGS, Western blot/Jess, flow cytometry, immunoassays, highcontent imaging, etc.
  • Design, plan, execute, analyze, interpret, and summarize target identification and validation experiments with a wide degree of independence within a team environment, with strong emphasis on CRISPR/Cas technology in diseaserelevant models
  • Participate in developing and establishing relevant new technologies, as needed
  • Consistently provide highquality data on time, document results as requested by project leaders/other stakeholders and record experiments in electronic lab notebooks
  • Write, review, and centrally store relevant SOPs
  • Train and supervise staff in designing and executing broad range of cellbased assays and readout technologies
  • Support scientific project leaders proactively in project execution with high attention to details

Your qualifications:

  • Successfully completed apprenticeship (BTA/CTA/MTA) or bachelor's/master's degree in the field of biological sciences with multiple years of professional handson experience in an academic, pharmaceutical or biotechnology environment
  • Strong background and handson experience in cell culture and genetic manipulation methods (e.g. transfections and infections)
  • Handson experience in molecular biology approaches for genotyping of cell lines beneficial
  • Sound understanding and experience in relevant techniques to detect effects of cell manipulation (Western Blotting, Genotyping, Immunofluorescence and/or FACS)
  • Some _in vitro_ pharmacology labbased research experience in an academic, pharmaceutical or biotechnology environment is an advantage
  • Ability to handle multiple concurrent activities and to work successfully under pressure to tight timelines
  • Selfstarter, independent, and flexible team player
  • Excellent communication skills in English

Our offer:

  • A permanent position within a vigorous and exciting professional environment promoted by an open culture and a spirit of community
  • A diverse, international workforce with a dynamic working environment that fosters creativity, innovations and teamwork
  • 30 days of annual holiday, monthly allowance for public transportation, and inhouse canteen
  • Capital forming benefits, flexible working hours, holiday pay, and annual bonus depending on performance
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