Scientist Medicinal Chemistry
Über Vijay Nimbarte:
Experienced medicinal chemist which includes a structure-based drug design approach supported by in-silico methods and tools. Experience in dealing with mg-100g scale covering a broad range of targets including heterocycles, nucleotides, and complex small biologically active molecules. Experience using most major purification and analytical method. A true team-oriented contributor.
August 2020 - Current (2 plus years) Post-Doctoral Scientist | Max Planck Institute for Medical Research, Heidelberg, Germany Supervisor: Prof. Dr. Kai Johnsson ▪ Design, synthesis, and development of clinical candidate for peripheral neuropathy by targeting Sepiapterin reductase enzyme ▪ Implement design aspects into small molecules by maintaining ideal CNS MPO criteria for peripheral restriction of small molecules ▪ Used ELN notebooks to enter data into project database and provided regular updates. ▪ Monitored company inventory to keep stock levels and databases updated. ▪ Collaborated with Lead discovery center, Dortmund, Germany to achieve desired ADME and DMPK profile to generate ideal Lead candidate for drug discovery program. ▪ Proved successful working within tight deadlines and a fast-paced atmosphere. ▪ Oversaw daily operations to ensure high levels of productivity.
March 2016 - June 2020 Ph.D., Marie Curie Early Stage Researcher | Goethe University, Frankfurt Supervisor: Prof. Dr. Harald Schwalbe ▪ Ph. D in Medicinal Chemistry: Marie curie early stage, Frankfurt am Main; Germany (with the highest distinction 1.0, magna cum laude) ▪ Thesis title: Design, Synthesis, and Evaluation of Novel c-MYC G-Quadruplex Stabilizing agents ▪ Published research finding in ChemMedChem, research paper entitles as " Synthesis and in vitro evaluation of novel 5-nitro indole derivatives as c-Myc G-Quadruplex binders with anticancer activity " ▪ Advanced knowledge of field continuously through personal coursework and additional study to best help professor and students. ▪ Taught small groups of students focused on specific parts of the coursework. Conducted research in medicinal chemistry for the development of novel small molecules to stabilize GQuadruplex sequence with a team of 6 graduates and with biochemistry and pharmacology faculties. ▪ Mentored students through office hours and one-on-one communication. ▪ Led courses independently with minimal oversight from professors. ▪ Completed paperwork, recognizing discrepancies and promptly addressing them for resolution. ▪ Supported advanced field research by assisting with experimental design, execution, and results tracking.
April 2014 - June 2015 Project Associate Medicinal Chemistry | University of Le Havre, France Supervisor: Prof. Dr. Adam Daïch ▪ Project title: Development of new pathways via Friedlander reaction, Click Chemistry, and Metal-Catalyzed reactions to functionalized Azaindole as promising platforms for the medicinal chemistry modulation and Immunological assays for antitumor activity. ▪ Developed small molecules selected by National Cancer Institute for 60 cancer cell line screening and for mechanistic investigations. ▪ Conducted research, gathered information from multiple sources, and presented results. ▪ Participated in continuous improvement by generating suggestions, and engaging in problem-solving activities to support teamwork. ▪ Developed team communications and information for meetings. ▪ Delivered all selected small molecules to NCI united states locations within specific timeframes.
October 2012 - March 2014 Research Assistant Medicinal Chemistry | CSIR, IICT, Hyderabad Supervisor: Prof. Dr. Ahmed Kamal ▪ Project title: Synthesis and characterization of PBD Based intercalating agents and novel tubulin polymerase inhibitors ▪ Gain expertise in drug design and modern synthetic techniques and methodologies ▪ Gain experience in scientific writing and publishing of manuscripts in the international medicinal chemistry journals
Ph. D: Medicinal and Pharmaceutical Chemistry 06/June/ 2020
Department of Organic Chemistry Goethe University - Frankfurt am Main, Germany ▪ Thesis: " Design, synthesis and biological evaluation of novel G-Quadruplex Stabilizing small molecules ▪ Relevant Coursework Completed: GLP & GMP guidelines ▪ Awarded Marie Curie Early Stage Research Fellowship ▪ Awarded BMLS achievement certificate for Ph.D. Research
M.S (Pharm): Medicinal and Pharmaceutical Chemistry 08/August/ 2012
Department of Medicinal Chemistry, NIPER Hyderabad, India ▪ Thesis: " Design, synthesis and biological evaluation of Novel Soluble Epoxy Hydrolase Inhibitors for antiinflammatory Effects” ▪ Gained knowledge in Medicinal Chemistry and Drug designed strategies ▪ Participated in drug discovery workshops and seminars ▪ Received NIPER research assistantship and GPAT fellowship ▪ Researched on Soluble epoxy hydrolase inhibitors
Bachelors in Pharmaceutical Sciences, Nagpur University, India 08/August/ 2010
▪ Gain knowledge about the basics of Pharmaceutical sciences ▪ Learned about Pharmaceutics, Pharmaceutical Chemistry, Pharmaceutical Analysis, Pharmacology, and Pharmacognosy
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