Research Assistant/ Phd Student - Halle (Saale), Deutschland - Martin-Luther-Universität Halle Wittenberg
vor 3 Wochen
Beschreibung
External Job Announcement
Reg.
Nr. 7-258/23-D
Creating Knowledge.
Since 1502:
Martin Luther University Halle-Wittenberg (MLU) offers a wide range of
largest university in Saxony-Anhalt was created in 1817 when the University of Wittenberg (founded in 1502)
merged with Friedrichs University Halle (founded in Today the university has 340 professors and 20,000
students. Research at the university focuses on nano and life sciences, the Enlightenment, society and culture._ _
Martin Luther University Halle-Wittenberg, Medical Faculty, Molecular Medicine of Signal Transduction,
offers the third-party funded position of a
Research Assistant/ PhD Student (m-f-d)
starting from for the duration of 3 years and in part-time (65%).
Salary will be in accordance with salary class 13 TV-L, pending classification based on individual capacities
and qualifications.
Funded by the German Research Foundation (DFG), this project focuses on the reconstruction of transcrip
- tional networks downstream of the MAPK signaling cascade. MAPK signaling plays a key role in the regula
- tion of cell proliferation, differentiation as well as survival. The constitutive activation of the MAPK signal
- ing cascade by activating mutations of its components, such as EGFR, RAS or BRAF, is one of the main
causes for the development of numerous types of cancer. Despite the clinical relevance of the MAPK signal
- ing cascade, the topology of the transcriptional networks it regulates is still largely unexplored. To investi
- gate these networks in more detail, orthogonal CRISPR screens will be combined with single-cell RNA se
- quencing (scRNA
- Seq) and computational methods for modeling transcription networks in close collabora
- lation of transcriptional networks downstream of the MAPK signaling cascade and thereby identify new
therapeutic targets for the treatment of MAPK-related cancers.
Tasks:
- Design and cloning of CRISPR sgRNA libraries
- Performance of CROP-Seq experiments in human cancer cell lines
- Bioinformatic analysis of the generated CROP-Seq data
- Scientific processing, presentation and publication of obtained results
- Independent project management
- Participation in national collaborations
- Opportunity for own scientific qualification
Requirements:
- Completed scientific university degree in the field of life sciences (Master)
- Extensive experience with molecular cloning techniques
- Experience with lentiviral transduction of human cells
- Experience with genome editing in human cells
- Experience with performing and analyzing scRNASeq experiments is an advantage
- Programming skills with R and/or Python are desirable
- Very good written and spoken English language skills
- Analytical and problemoriented thinking
- Structured and thorough way of working
- Ability to work in a team
- Ability to cooperate
of Comparability for Foreign Higher Education Qualifications issued by the Central Office for Foreign Education
For further information, please contact Jun.
Prof. Michael Böttcher,
- versity Halle-Wittenberg, Medical Faculty, Molecular Medicine of Signal Transduction, Jun.
Prof. Michael Bött
only be returned if a prepaid return envelope has been attached.
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