Phd Candidate - Duesseldorf, Deutschland - Universitätsklinikum Münster

Universitätsklinikum Münster

Geprüftes Unternehmen

Duesseldorf, Deutschland

vor 2 Wochen

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

Job Id: 8784We are looking for you for the
Department of Internal Medicine B in the Research Lab at the earliest possible date for a limited period of 3 years

Part-time employment with 65%

Salary in accordance with the provisions of the TV-L (E13)
In liver cirrhosis, portal hypertension and systemic inflammation lead to complications and decompensation with a high mortality rate.

It is assumed that bacterial infections and translocation due to the disturbed intestinal barrier trigger systemic inflammatory reactions that lead to acute decompensation and acute-on-chronic liver failure (ACLF).

Despite increasing research, the mechanisms by which the gut-liver axis influences the decompensation of liver cirrhosis remain unknown.

By integrating metabolomic data from the portal vein and hepatic vein with the corresponding circulating 16S rRNA amplicon profiles from buffy coat and stool of TIPS patients, two very interesting metabolites could be identified that explain the influence of the gut-liver axis in the decompensation of liver cirrhosis and are suitable for therapeutic approaches.

The aim of this study is to identify specific species of the gut microbiome that are involved in the alteration of metabolites.

These findings will provide new insights into how these possibly gut microbiome-derived or metabolized metabolites contribute to decompensation in patients with liver cirrhosis.

In addition, we aim to test new therapeutic options to prevent decompensation of liver cirrhosis by targeting specific species of the gut microbiome involved in the synthesis and/or modification of these metabolites to prevent further decompensation by influencing the gut-liver axis.

We are a dynamic team and look forward to nice, team-oriented support

Required qualifications:

A completed Master's or Diploma degree in the field of biology, biochemistry, technical biology, molecular medicine or similar.
You have a strong interest in experimental research and the willingness to work experimentally in vivo (with rats and mice)
Experience in molecular biology work is required
Conscientious execution and documentation of the work in compliance with the given deadlines
A quick grasp and ability to work in a team paired with an independent and precise way of working is required
Knowledge of bioinformatics is an advantage
Authorization to work experimentally in vivo (FELASA certificate) is an advantage
Knowledge of English and interdisciplinary thinking are required
Good communication and interaction skills, enjoy working with cooperation partners
Strong commitment and ability to work independently

We offer you:

A basic scientific and clinically interesting research project in the field of hepatology/gastroenterology
A wide range of molecular biological methods
A dynamically developing clinic in which you will be part of an ambitious research group
Close cooperation with national and international partners
A friendly working atmosphere in a highly motivated team
The opportunity to participate in international conferences Mobility: possibility of a job ticket, good transport connections, parking facilities
Münster University Hospital is one of the leading hospitals in Germany. Such a position is not only achieved through size and medical success. The commitment of each individual is important. We need your commitment to be able to achieve great things for our patients, even on a small scale. To this end, we offer you many opportunities so that you can continue to grow yourself.
Due to legal requirements working with us is only permitted with complete vaccination against measles.

At the UKM we have one common goal: We help people get healthy again and stay healthy - giving modern highly advanced medical technologies a human face.