Postdoc - Wissenschafltiche:r Mitarbeiter:in (M/F/d) - Heidelberg, Deutschland - Universitätsklinikum Heidelberg

Universitätsklinikum Heidelberg

Geprüftes Unternehmen

Heidelberg, Deutschland

vor 1 Woche

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

The
Pharmacological Institute of the
Medical Faculty of the
University of Heidelberg has a vacancy for a PostDoc.

In the department of Prof. Marc Freichel, Ca2+ signaling pathways in cellular and integrative organ functions are studied.

The main interest is in TRP and Ca2+ channels in the plasma membrane and in acidic organelles such as endo-lysosomes and their role in Ca2+-dependent signaling and gene programs with a focus on cells of the cardiovascular system (cardiomyocytes, cardiac fibroblasts, macrophages, platelets, chromaffin cells) and the processes regulated by them such as contractility and metabolism, secretion of neurotransmitters and activation of the autonomic nervous system.

In mast cells, Ca2+-dependent signaling pathways and gene programs for the generation and release of inflammatory mediators are being investigated.

The relevance of these processes is investigated in cardiac diseases such as maladaptive remodeling and in the development of diabetes mellitus-associated long-term sequelae within several research consortia (German Center for Cardiovascular Diseases DZHK, TR-SFB 152, SFB 1328, SFB 1550).

The laboratory has many years of experience with transgenic approaches including genome editing (CRISPR/Cas9, base und prime editing), in cell (ES, iPS) and animal models as well as AAV vector technologies used in the generation of disease models and for the identification of new drug targets as well as in the validation of small molecule compounds.

Job-ID:

V

Pharmakologisches Institut

Location:

Heidelberg

Job Category:

Science and teaching

Working hours:

full-time

Published:

Limitation:

Temporary (3 years)

Contract:

TV-L

Your Profile:

***We are looking for highly motivated scientists with an interest in independent scientific work, self-motivation and the ability to work in a team and knowledge or previous experience in one or more of the following areas:

Isolation / culture / characterization of primary cell systems, stem cells, organoids, FACS, histology
Molecular biology and biochemical methods, performance and bioinformatics analysis of gene expression using OMICs approaches, metabolome, proteome, or secretome analyses, respectively
Fluorescence microscopy, electrophysiology
Genome editing
Performing animal studies with disease models
Very good knowledge of English

What we offer:

***- A friendly and collegial working atmosphere and a very diversified activity

The opportunity for independent and teamoriented work
Goaloriented, individual training and further education opportunities in the abovementioned techniques, research areas as well as in pharmacology and drug development (if applicable, further education to become a specialist pharmacologist of the DGPT)
Targeted initial training
Collectively agreed remuneration, attractive company pension scheme (VBL)
30 days vacation
Sustainable travel: job ticket (Deutschlandticket)
Familyfriendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
Wide range of health, prevention and sports offers

Contact & Application:

***
Are you interested?
Pharmakologisches Institut

Prof. Dr. Marc Freichel
Im Neuenheimer Feld 366

HeidelbergWe stand for equal opportunities. Severely disabled persons are given priority in the case of equal suitability.

The University Hospital aims to generally increase the proportion of women in all areas and positions in which women are underrepresented.

Qualified women are therefore particularly encouraged to apply. Full-time positions are generally divisible, unless there are official or legal reasons to the contrary.