- Implement and qualify mass spectrometry equipment at different Charles River sites in Germany and USA
- Develop and implement highly complex and state-of-the-art mass spectrometry-based methods to identify, characterize, and quantify proteins from complex protein mixtures.
- Operate and maintain high-resolution tandem mass spectrometers such as Thermo Scientific Orbitrap Exploris, Lumos, and Q-Exactive and the requisite nano-scale liquid chromatography and capillary electrophoresis systems.
- Identify, advise or assist investigators with developing strategies for sample preparation for the use of gel electrophoresis, liquid chromatography, capillary electrophoresis, and mass spectrometry to identify, quantify, and characterize proteins and their modifications
- Perform routine testing in techniques such as the following with a degree of reliability, efficiency and accuracy. Total proteomics, identification and quantification of host cell proteins (HCP) Targeted peptide quantification Peptide Mapping by LC-UV/MS (MS) Intact Molecular Weight Analyses by LC-UV/MS Sample preparation techniques including protein concentration determination, SDS PAGE, SPE, HPLC Fraction Collection Glycosylation site Mapping Released N- and O- Linked Glycosylation Profiling Residuals and impurities investigations Methodologies developed for Orbitrap, QTOF, and Triple Quadrupole
- Teach staff, students, or fellows advanced techniques in protein analysis by mass spectrometry used in the center through informal discussions or formal workshops offered by the facility.
- Expand or develop new skills, as needed, based on information from literature, in collaboration with other laboratories or vendors, or by interacting with colleagues at meetings or professional presentations.
- Responsible for maintaining high-end mass spectrometers, developing and following SOPs, developing and maintaining collaborative connections with the investigators.
- Independent research in technological developments in proteomics will be strongly encouraged.
- Education: Bachelor's degree (B.A. /B.S.) or equivalent in Chemistry/ Biochemistry or related scientific discipline. M.S. or Ph.D. preferred.
- Experience in Top-Down proteomics, targeted proteomics (SRM/MRM), quantitative proteomics, glycoproteomics and phosphoproteomics is preferred.
- Knowledge of mass spectrometry, protein separation, and identification methods.
- Experience in leading and motivating people
- Willingness to travel to EU and non-EU based Charles River sites as needed
- Strong organizational skills and talent to drive operations in a fast-changing environment
- Ability to promote constructive and open collaborations and interactions with experts and between different teams in a (matrix) organization
- Very good communication and presentation skills to effectively communicate with various target groups
- Fluency in both English and German (oral and written)
- an unlimited full-time position with varied, demanding activities
- a future-oriented global industries and company
- flexible working hours
- an active participation in shaping your field of activity in a motivated team
-
Mass Spectrometry Scientist
vor 6 Tagen
Charles River Laboratories, Inc. Erkrath, DeutschlandSeit fast 75 Jahren arbeiten die Mitarbeiter von Charles River zusammen, um bei der Entdeckung, Entwicklung und sicheren Herstellung neuer Arzneimitteltherapien zu helfen. Wenn Sie sich unserer Familie anschließen, haben Sie einen bedeutenden Einfluss auf die Gesundheit und das W ...
-
Mass Spectrometry Scientist
vor 6 Tagen
Charles River Laboratories, Inc. Erkrath, DeutschlandFor 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your backgr ...
-
Mass Spectrometry Scientist
vor 4 Tagen
Charles River Laboratories, Inc. Erkrath, DeutschlandFor 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your backgr ...
-
Mass Spectrometry Scientist
vor 4 Tagen
Charles River Erkrath, DeutschlandFor 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your backgr ...
-
Mass Spectrometry Scientist
vor 5 Tagen
Charles River Laboratories, Inc. Erkrath, DeutschlandFor 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your backgr ...
-
Scientist (F/m/x) Field of Mass Spectrometry of
vor 5 Tagen
Universitätsklinikum Köln AöR Duesseldorf, Deutschlandas soon as possible · full-time; initially limited until August 1, 2024 within the scope of a parental leave replacement · Your salary will be based on TV-L · - Your tasks · Planning and execution of mass spectrometric analyses of small metabolites (lipids, polar/ionic metabolite ...
-
Protein Engineering Biochemistry Scientist
vor 3 Tagen
Bayer Wuppertal, Deutschland**At Bayer we're visionaries, driven to solve the world's toughest challenges and striving for a world where ,Health for all, Hunger for none' is no longer a dream, but a real possibility. We're doing it with energy, curiosity and sheer dedication, always learning from unique per ...
-
Accurate Mass Workflows Specialist
vor 2 Tagen
SCIEX Duesseldorf, DeutschlandFor over 50 years, SCIEX has been developing groundbreaking technologies and solutions in mass spectrometry and capillary electrophoresis. Our products enable our customers to quickly respond to environmental hazards, better understand biomarkers relevant to disease, improve pati ...
-
Biopharma Sales Specialist
vor 6 Tagen
AB SCIEX Germany GmbH Duesseldorf, DeutschlandFor over 50 years, SCIEX has been developing groundbreaking technologies and solutions in mass spectrometry and capillary electrophoresis. Our products enable our customers to quickly respond to environmental hazards, better understand biomarkers relevant to disease, improve pati ...
-
Biopharma Sales Specialist
vor 1 Woche
SCIEX Duesseldorf, DeutschlandFor over 50 years, SCIEX has been developing groundbreaking technologies and solutions in mass spectrometry and capillary electrophoresis. Our products enable our customers to quickly respond to environmental hazards, better understand biomarkers relevant to disease, improve pati ...
-
Head of Proteomics and Metabolomics
vor 1 Woche
CeMM - Forschungszentrum für Molekulare Medizin GmbH Österreich, Deutschland GanztagsCeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences is an international, independent and interdisciplinary research institution located at the Campus of the Vienna General Hospital and Medical University of Vienna. We are looking for scientists th ...
-
Universitätsmedizin Essen Essen, Deutschland GanztagsDetails zu diesem Stellenangebot · Jobtitel Wissenschaftliche/r Mitarbeiter/in MS-basierte Proteo-Metabolomik (Senior Scientist Proteo-Metabolomics) (m/w/d) Einsatzbereich Research Alliance Center OneHealth Ruhr - Abteilung für Metabolismus, Seneszenz und Autophagie Stellenart ...
Mass Spectrometry Scientist - Erkrath, Deutschland - Charles River
Beschreibung
For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.
.
For our Biologics site located in Erkrath, Germany we are seeking
an experienced
Sr. Scientist as a Mass Spectrometry & Proteomics Specialist (m/f/d)
Responsibilities
Qualifications
This position would suit an ambitious, flexible, and team-orientated individual who is motivated to achieve results. The main base of this position would be Erkrath, Germany.
You will also be expected to have:
What we offer
Are you interested?
Please apply under job ID via our career portal with your application documents in English and your earliest possible starting date.
We look forward to receiving your application
Charles River Laboratories Germany GmbH
Human Resources
Max-Planck-Str. 15a
40699 Erkrath
Phone: Michaela Klein)
About Biologics Testing Solutions
With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs. Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.
About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.
At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.