Research Associate - Planegg, Deutschland - iOmx Therapeutics AG

iOmx Therapeutics AG

Geprüftes Unternehmen

Planegg, Deutschland

vor 3 Wochen

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

Your Tasks and Responsibilities:

As a part of the Research Department, you will contribute to the discovery and characterization of novel immune-checkpoint targets and actively participate in the evolution of our proprietary screening and validation platform.

You will work in a modern, semi-automated laboratory, and will be eager to continually evaluate and employ new state-of-the-art techniques for advancing our target-tailored drug screening efforts.

Some of your daily tasks will involve:

Validation of gene function in modulating immune cell (lymphoid and myeloid) responses using stateoftheart methodologies (CRISPR, RNAi etc.)
In vitro primary immune cellbased assays such as coculture assays, immune cell activation and cytotoxicity assays
Improvement and implementation of our proprietary highthroughput genetic screening platform
Execution of immunological endpoint assays such as flow cytometry, ELISA, multiplex analysis and image analysis using IncuCyte live cell imaging device
Target pathway analysis including overexpression, phosphoprotein analysis, transcriptomic sequencing
Participate routinely in laboratory management and organization.
Execution of experiments both independently and in a team, including diligent analysis, documentation, and presentation of your results in internal team meetings

What we are looking for:

You hold a university degree (Bachelor's or Master's) in biology, molecular medicine, biotechnology, or a related field, or have completed a vocational training as laboratory assistant such as BTA, MTA, CTA and have at least 3 years of relevant work experience, preferably in an industry setting
You have demonstrable experience with CRISPR/Casbased genome editing methodology or in transfection/transduction of primary human immune cells or cell lines
You possess handson experience in conducting immune cellbased functional assays (cytotoxicity assays, cytokine release assays, ELISA, beadbased multiplex assays, macrophage polarization assays etc.)
You are familiar with standard cellular and molecular biology methods such as cloning, transduction/transfection of expression vectors in desired cell types, mutant generation, western blot, RNA sequencing preparation, phoshpoflow or plex analysis
You are experienced in using data analysis software such as GraphPad Prism and Flow Jo
You are motivated to work independently and collaboratively in a fastpaced biotech environment to meet project goals
You are fluent in English (spoken and written)

Why to join iOmx?:

We are a young biotechnology company with about 50 employees in Martinsried/Munich.

We are working in flat hierarchies with short decision-making processes and offer a rewarding career in a welcoming, trusting and international work environment.

By joining us you can expect the following:

Opportunity for personal development
Growthoriented and innovationdriven company culture
30 days paid vacation
Flexible working time and much more

About us:

- i_

Omx Therapeutics is a clinicalstage company in the field of immunooncology located in Martinsried/Munich, Germany._
We are focusing on the development of firstinclass cancer immunotherapies, addressing novel immune evasion biologies, which are hijacked by tumors and their microenvironment._
We are looking for highly motivated, selfdriven and competent colleagues who share our vision and wish to contribute to translating this vision into reality._