Master Thesis with The Topic "functional Analysis - Duesseldorf, Deutschland - Deutsches Diabetes Zentrum (DDZ)

Deutsches Diabetes Zentrum (DDZ)

Geprüftes Unternehmen

Duesseldorf, Deutschland

vor 2 Wochen

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

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**Institut für Vaskular
- und Inselzellbiologie (Direktor: Univ.
Prof. Dr. rer. nat.

Eckhard Lammert), Arbeitsgruppe Betazelldefekte (Leiter:
Dr. rer. nat. Bengt-Frederik Belgardt, Dipl.

Biol.)**The German Diabetes Center (DDZ) the Leibniz Institute for Diabetes Research at Heinrich Heine University (HHU) in Düsseldorf was funded by the Federal Ministry of Health and Ministry of Innovation Science and Research of the State of North Rhine Westphalia.

The DDZ as an interdisciplinary Institute links molecular and cell biological basic research with clinical investigation.

The Institute for Vascular and Islet Cell Biology (director: Prof. Dr. Eckhard Lammert) investigates the molecular mechanisms of type 2 diabetes using molecular biology and biochemical _in vitro_, _ex vivo_ and _in vivo _approaches.

MASTER THESIS with the topic

"Functional analysis of a novel protein family in insulin secretion regulation
"

Background

We have recently used a Multi-Omics approach to identify a protein family that binds to specific lipid species and is able to regulate insulin secretion in pancreatic beta cells, although the specific roles of several family members remain unknown.

Ihr Aufgabengebiet umfasst:

Role and Responsibilities
Use of CrispR/Cas9, RNAi and/or overexpression to manipulate relevant genes/proteins

Functional analyses of KO cell lines and pancreatic islets using e.g. insulin secretion assays and live-cell imaging

Wir erwarten von Ihnen:

Requirements:

Bachelor degree in biology, biochemistry, biomedicine or a similar field.

Willingness to work with
_in vitro _/
_ex vivo / in vivo _models for beta cell dysfunction (FELASA B is of advantage)

Reliable performance, flexibility and teamwork skills.

Self-motivated and driven to continuous improvement, good knowledge of the English language.

Project start in January, February or at the latest, March 2023

Wir bieten Ihnen:

We offer:

Hands-on work with modern genetic manipulation methods, biochemical and computational analyses

Participation in manuscript preparation

Detailed training and daily interactions with group members and PI

Further informations:

The DDZ is committed to family-friendly working conditions and equal gender policy. Since May 2011, the DDZ is a "Career and Family" audit-acknowledged Center.

Females are encouraged to apply, and in the case of equal qualification will be given preference.

Persons with disabilities will be given preference.