Postdoc - Mechanisms to Control Alternative - Munich, Deutschland - Helmholtz Zentrum München

Helmholtz Zentrum München

Geprüftes Unternehmen

Munich, Deutschland

vor 3 Wochen

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

:
Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

The UNLEASH Synergy project, which is jointly funded by the European Research Council (ERC) and UK Research and Innovation (UKRI), is a 6-year international collaborative programme that will study mechanisms controlling alternative pre-mRNA splicing in human cells and how it can be modulated using small molecules.

The UNLEASH team are taking an interdisciplinary approach to understand splice site selection, with chemical, molecular, cellular and structural biology, combined with proteomics, computational analysis and deep learning.

Our aim is to identify new, drug-like small molecules that can control alternative splicing decisions and characterise their detailed mechanisms of action.

Ultimately, this will help us to facilitate the development of new therapeutics, targeting alternative splicing events for the treatment of human diseases of current unmet need.

The UNLEASH team combines the complementary expertise of the research groups of Profs.

David Gray and Angus Lamond (University of Dundee, UK), Michael Sattler (Helmholtz Munich, Germany) and Juan Valcárcel (Center for Genomic Regulation, Barcelona, Spain).

Opportunities will be available also for joint appointments and mobility will be encouraged for team members to spend time working across the respective sites.

The UNLEASH project provides a unique opportunity to contribute to a truly interdisciplinary European collaborative project with the potential to deliver a major advance in biomedical research.

Additionally, you will have access to state-of-the-art wet-lab facilities and outstanding cryo-EM, NMR and computational infrastructure at Helmholtz Munich.

We are offering two positions as

Postdoc - Mechanisms to Control Alternative Splicing (f/m/x

Full time

Garching

Postdocs

Responsibilities:

Integrative structural biology of proteinRNA complexes and small molecule interactions, focusing on cryoEM singleparticle analysis, integrated with Xray crystallography and NMR spectroscopy
Protein/RNA biochemistry, reconstitution and purification of proteinRNA complexes from eukaryotic and bacterial cell culture
Biochemical and biophysical analysis of proteinRNA interactions, splicing assays activity in cells and extracts

Your qualifications

Doctoral degree in natural sciences (biochemistry, chemistry, bio/physics, biology, or related discipline)
Excellent track record, research achievements and publications
Expertise in at least one of these areas:

- cryo

EM SPA and integrative structural biology, biochemical and biophysical methods, experience with XL-MS, (experience with crystallography and/or NMR is a plus)

- cell culture (bacterial and eukaryotic) for protein expression and purification of protein complexes, and biochemical/functional assays

Knowledge and interest in understanding mechanisms of splicing regulation
Strong motivation, scientific curiosity, and commitment to scientific excellence
Excellent writing and communication skills and motivation to publish
Team player and enthusiasm to work in an international multidisciplinary and collaborative environment

What we offer you

work-life balance
flexible working hours & working-time models
continuous education and training
30 days annual leave
on-site health management service
excellent research infrastructure on-site nursery & holiday care
elder care company pension scheme discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide.

With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited to two years, under certain circumstances an extension can be arranged.

If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree.

Interested?
If you have further questions, simply contact Karen Biniossek, , who will be happy to be of assistance. Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Bavarian NMR Center
Institute of Structural Biology
Ernst-Otto-Fischer-Straße 2

85748 Garching