Postdoctoral Researcher with Focus On Rna Biology - Heidelberg, Deutschland - Universitätsklinikum Heidelberg

Universitätsklinikum Heidelberg

Geprüftes Unternehmen

Heidelberg, Deutschland

vor 2 Wochen

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

wanted
for the next possible date at the at the
Department of Internal Medicine V (Hematology, Oncology and Rheumatology).

We are looking for a highly motivated, skilled and communicative Postdoc (M/F) with background in RNA biology and splicing analyses who is interested to perform competitive high quality scientific research in the field of acute myeloid leukemia (AML) and hematopoietic stem cell research. Our team is focused on the biology of leukemic stem cells and therapy resistance. We aim to understand how stemnessassociated genes participate in alternative splicing and cooperate with splicing factor mutations in AML. To follow this question a broad number of in vitro and in vivo models are investigated. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients at diagnosis and relapse. The postdoc will work in a small research team of enthusiastic biologists & medical scientists embedded in a larger group of researchers at Medical Department V focused on AML research. In addition, the postdoc will be part of the Molecular Medicine Partnership Unit (MMPU) "Stem Cell Niche Networks"

Job-ID:

V

Klinik für Hämatologie, Onkologie und Rheumatologie

Location:

Heidelberg

Start date:

as of now

Job Category:

Science and teaching

Working hours:

full-time

Published:

Limitation:

Temporary (2 years, extension is sought)

Contract:

TV-L

Your Tasks:

***- Generate and analyse short
- and long-read RNA sequencing data with special focus on alternative splicing and transcript variant expression

Perform proteinprotein and proteinRNA pulldown experiments
Characterize the functional role of stemnessassociated genes in primary human AML using lentiviral transduction, CRISPR/Cas9 and xenotransplantation assays
Use confocal imaging to determine subcellular localization and distribution of proteins of interest
Perform preclinical in vitro and in vivo studies to identify novel targets and combination treatments in AML

Your Profil:

***- PhD in biology, biochemistry or equivalent with background in RNA biology and splicing analyses

Highly dedicated to science, highly motivated and selforganized to work in a competitive research field
Broad expertise in cellculture, molecular and biochemical techniques (Western blotting, gene expression analysis, cloning, cell culture, flow cytometry etc.)
Good knowledge of and experience with graphic programs, statistical software, online tools (e.g. Illustrator, ImageJ, GraphPadPrism, BLAST), basic knowledge in data analysis with R, experience with mouse models is a plus
Strong communication skills (oral presentations and writing), fluent in written and spoken English

We offer:

***- Goal-oriented, individual training and development opportunities

Working with the latest techniques
Flexible working hours within the framework of flexitime
Regular team meetings
Interdisciplinary cooperation with EMBL, Heidelberg
Possibility to take over project responsibility
Scientific publications

Contact & Application:

***
Interested?
Applications will be accepted until direct online.

Klinik für Hämatologie, Onkologie und Rheumatologie

Dr. med. Caroline Pabst
Im Neuenheimer Feld 410

Heidelberg

Tel:

- **We stand for equal opportunities. Severely disabled persons are given priority in the case of equal suitability. The University Hospital aims to generally increase the proportion of women in all areas and positions in which women are underrepresented. Qualified women are therefore particularly encouraged to apply. Full-time positions are generally divisible, unless there are official or legal reasons to the contrary.