Phd Student in Protein Fluid Biomarkers for - Stuttgart, Deutschland - Hertie Institute for Clinical Brain Research

Beschreibung

PhD student in protein fluid biomarkers for neurodegenerative diseases

:

• Employer
• Hertie Institute for Clinical Brain Research
• Location
• Tübingen, Baden-Württemberg (DE)
• Salary
• Salary

will be determined according to EU MSCA salary regulations

• Closing date 11 Jun 2024
• Discipline

Life Science
Job Type
PhD Position
Employment - Hours
Full time
Duration
Fixed term
Qualification
Masters
Sector
Academia- You need to sign in or create an account to a job.


PhD student

in protein fluid biomarkers for neurodegenerative diseases

The Hertie Institute for Clinical Brain Research (HIH), together with the Department of Neurology, forms the Center for Neurology at the University of Tuebingen.

It is dedicated to basic and translational research in neurological diseases.

Together with the several other highly advanced neuroscience institutes, it is part of the TuebingenNeuroCampus (TNC), here working closely together also with the German Center for Neurodegenerative Diseases (DZNE).

Scientists in the more than 100 active research groups of the TNC pursue theoretical, system-neuroscientific, molecular, and clinical research approaches in their entire breadth using a wide range of methods.

The research division "Translational Genomics of Neurodegenerative Diseases" of Prof. Synofzik is currently looking for a
PhD student for 3 years (extension possible) - position available immediately.

Our division focuses on genomics, pathophysiology and translational biomarker research in the field of neurodegenerative diseases, with a special focus on genetic ataxias, motor neuron diseases, and dementias.

Prof.

Synofzik coordinates several large trans-European consortia on translational neurodegeneration in rare movement disorders and serves as PI of several large-scale national and international longitudinal cohort studies.

We offer excellent projects and training in neurodegeneration and molecular biology research. A wide range of molecular, protein biochemical and cell biological methods are applied in the lab (e.g. cutting-edge ultra-sensitive protein analysis including Simoa, Luminex and Singulex technology, ELISAs, western blotting, exome/genome sequencing, qPCR, and antisense oligonucleotide [ASO] development from bench to bedside and back). Biomarkers are identified in cell culture models, human and murine blood and/or CSF, and validated in patient cohorts.

The PhD project.

You will be integrated in several translational projects as the key person to identify and validate novel fluid biomarkers in dementia (fronto-temporal dementia and Alzheimer's disease) and ataxia disorders (ARSACS and COQ8A).

You will identify novel biomarkers in fluids from humans, mice and cell culture disease models with unbiased mass spectrometry proteomics and targeted immunoassays.

You will receive excellent training in cutting-edge molecular biology methods and assay development (including MSD, Simoa, Singulex and Luminex technology, which are all directly available and established on site), collaborate with biotechnology cores across the Tuebingen research campus, and work collaboratively with our team to report the results and progress at conferences and scientific journals.

This position will be part of an
Integrated Doctoral Network programme "Medicine Made to Measure" (MMM) supported by the European Union Horizon Marie Sklodowska-Curie Actions programme (MSCA).

What we are looking for

:

• You have a Master's degree in Biochemistry, Biology, Bioinformatics, Molecular Genetics, or related life sciences.
• You should have good communication skills, attention to detail, and flexibility to work both independently and collaboratively.
• Very good proficiency in English (oral and written) is mandatory.
• You have not have resided or carried out your main activity (work, studies, etc.) in Germany for more than 12 months in the last 36 months

What we are offering

:

• A challenging interdisciplinary translational project that is integrated into the EUfunded
  Integrated Doctoral Network "Medicine Made to Measure" (MMM) supported by the European Union Horizon Marie Sklodowska-Curie Actions programme (MSCA). This PhD training network will allow for excellent continuous training and mobility allowances across toplabs in Europe working on the same topic.

:

• Supervised handson training in molecular and cell biology with a broadrange of wellestablished methodologies in our lab
• Integration into a dynamic, multiprofessional international team comprising Post-Docs, PhD students, and technicians, fostering collaborative exchange and diverse perspectives
• Weekly multiprofessional interactive lab meetings, where you'll actively participate in discussions, present research findings, and exchange insights with peers
• Personalized project mentoring, teaching, and multistep career guidance through regular oneonone meetings with the PI
• Affiliation with the Graduate Training Center of N