Phd - Medicine Made to Measure (M/F/d) - Heidelberg, Deutschland - Universitätsklinikum Heidelberg

Universitätsklinikum Heidelberg

Geprüftes Unternehmen

Heidelberg, Deutschland

vor 3 Wochen

Geschrieben von:

Lena Wagner

beBee Recruiter

Beschreibung

searched at the
Department of Neurology, in the field of neurodegenerative diseases (AG Schüle) for MMM (Medicine Made to Measure) development of tailored antisense oligonucleotide (ASO) therapies for treatment of nano-rare disease mutations.

Modern medicine seeks to personalize diagnosis and treatment to the needs of individual patients.

This need is heightened in particular for those individual patients where no treatments are available - and where current standard treatment development paradigms exclude to generate such.

The ultimate goal of the European Doctoral Network 'Medicine made to Measure' (MMM) is to go even beyond the latest genetic medicine approaches, implementing a novel paradigm of treatment development: the field of single patient tailored antisense oligonucleotide (ASO) treatments for patients with nano-rare disease mutations. Specifically, MMM will develop core modules of a novel "out-of-the-box", but still EMA-advised treatment development path for these patients - from omics-based theranostics, via preclinical target validation to innovative trial methodology and a pioneering ethical framework for individualized genetic therapies.

Job-ID:

V

Neurologische Klinik

Location:

Heidelberg

Job Category:

Science and teaching

Working hours:

full-/ part-time (first 6 months 65%, remaining 30 months 100%)

Published:

Limitation:

Temporary (36 months)

Contract:

TV-L

your tasks:

***- Optimize a pipeline for the detection of 'treatable' mutations in rare disease genes based on genome and transcriptome sequencing datasets.

Develop an iPSCbased human model system for exon skipping using genomic engineering techniques such as CRISPR/Cas9 and base editing.
Employ RNAbased therapeutic approaches, such as antisense oligonucleotides or RNA interference, to target diseaseassociated transcripts and proteins
Develop efficacy and toxicity assays for RNAbased therapies in stem cell culture

your profil:

***- Expertise in standard molecular techniques, including molecular genetics, protein biochemistry and cell biology.

Previous experience in stem cell culture, RNA therapy, genome editing or analysis and interpretation of NGS data is highly welcome.
Effective written and oral communication skills in English, with the ability to present research findings to scientific and nonscientific audiences.
Strong organizational skills, attention to detail, and the ability to meet project deadlines.

For further informationen please visit
Doctoral Networks | Marie Skłodowska-Curie Actions ).

What we offer:

***- The unique opportunity to spend two secondments in the lab of other partners in the MMM network including one academic and one industry partner

Stateoftheart facilities, resources, and a vibrant scientific community in one of the most beautiful cities in Germany.
A young and motivated lab that values creativity, collaboration, and scientific excellence.
Application and access to cuttingedge methods and technologies, including personalized RNA therapies, stem cell modelling, CRISPR/Cas9 genomic engineering.
Individual career development support by personalized career planning, mentorship, skills assessment and development, performance feedback and recognition, networking and professional development opportunities etc.
International collaborations and multidisciplinary approaches.

Contact & Application:

***- A motivation letter

Copies of your relevant certificates
Names and contact details for at least 2 potential referees

Interested?
Neurologische Klinik

Prof. Dr. Rebecca Schüle
Sektion Neurodegeneration
Im Neuenheimer Feld 400

HeidelbergWe stand for equal opportunities. Severely disabled persons are given priority in the case of equal suitability.

The University Hospital aims to generally increase the proportion of women in all areas and positions in which women are underrepresented.

Qualified women are therefore particularly encouraged to apply. Full-time positions are generally divisible, unless there are official or legal reasons to the contrary.